abstract：:Recent reports suggest that human genogroup II genotype 17 (GII.17) noroviruses are increasing in prevalence. We analyzed the evolutionary changes of three GII.17 capsid protruding (P) domains. We found that the GII.17 P domains had little cross-reactivity with antisera raised against the dominant GII.4 strains. X-ray...

journal_title：Journal of virology

authors： Singh BK,Koromyslova A,Hefele L,Gürth C,Hansman GS

更新日期：2015-12-23 00:00:00

abstract：UNLABELLED:Children with acute respiratory syncytial virus (RSV) infection often develop sequelae of persistent airway inflammation and wheezing. Pulmonary C fibers (PCFs) are involved in the generation of airway inflammation and resistance; however, their role in persistent airway diseases after RSV is unexplored. Her...

journal_title：Journal of virology

authors： Zang N,Zhuang J,Deng Y,Yang Z,Ye Z,Xie X,Ren L,Fu Z,Luo Z,Xu F,Liu E

更新日期：2015-12-16 00:00:00

abstract：UNLABELLED:HIV-1 Vpu decreases the exposure of epitopes within the viral envelope glycoprotein (Env) on the surface of infected cells by downregulating both BST2 and CD4. To test the hypothesis that inhibiting Vpu activity would increase the exposure of these epitopes and sensitize infected cells to antibody-dependent ...

journal_title：Journal of virology

authors： Tokarev A,Stoneham C,Lewinski MK,Mukim A,Deshmukh S,Vollbrecht T,Spina CA,Guatelli J

更新日期：2015-12-16 00:00:00

abstract：UNLABELLED:The cellular response to virus infection is initiated when pathogen recognition receptors (PRR) engage viral pathogen-associated molecular patterns (PAMPs). This process results in induction of downstream signaling pathways that activate the transcription factor interferon regulatory factor 3 (IRF3). IRF3 pl...

journal_title：Journal of virology

authors： Pattabhi S,Wilkins CR,Dong R,Knoll ML,Posakony J,Kaiser S,Mire CE,Wang ML,Ireton RC,Geisbert TW,Bedard KM,Iadonato SP,Loo YM,Gale M Jr

更新日期：2015-12-16 00:00:00

abstract：UNLABELLED:Demonstrating direct interactions between host and virus proteins during infection is a major goal and challenge for the field of virology. Most protein interactions are not binary or easily amenable to structural determination. Using infectious preparations of a polerovirus (Potato leafroll virus [PLRV]) an...

journal_title：Journal of virology

authors： DeBlasio SL,Chavez JD,Alexander MM,Ramsey J,Eng JK,Mahoney J,Gray SM,Bruce JE,Cilia M

更新日期：2015-12-09 00:00:00

abstract：UNLABELLED:Lifelong antiretroviral therapy (ART) for HIV-1 does not diminish the established latent reservoir. A possible cure approach is to reactivate the quiescent genome from latency and utilize immune responses to eliminate cells harboring reactivated HIV-1. It is not known whether antibodies within HIV-1-infected...

journal_title：Journal of virology

authors： Lee WS,Richard J,Lichtfuss M,Smith AB 3rd,Park J,Courter JR,Melillo BN,Sodroski JG,Kaufmann DE,Finzi A,Parsons MS,Kent SJ

更新日期：2015-12-09 00:00:00

abstract：UNLABELLED:Japanese encephalitis virus (JEV) membrane (M) protein plays important structural roles in the processes of fusion and maturation of progeny virus during cellular infection. The M protein is anchored in the viral membrane, and its ectodomain is composed of a flexible N-terminal loop and a perimembrane helix....

journal_title：Journal of virology

authors： de Wispelaere M,Khou C,Frenkiel MP,Desprès P,Pardigon N

更新日期：2015-12-09 00:00:00

abstract：UNLABELLED:Venezuelan equine encephalitis virus (VEEV) is an important human and animal pathogen, for which no safe and efficient vaccines or therapeutic means have been developed. Viral particle assembly and budding processes represent potential targets for therapeutic intervention. However, our understanding of the m...

journal_title：Journal of virology

authors： Reynaud JM,Lulla V,Kim DY,Frolova EI,Frolov I

更新日期：2015-12-09 00:00:00

abstract：UNLABELLED:Influenza A virus (IAV) affects the upper and lower respiratory tracts and rapidly induces the expression of mucins, which are common O-glycosylated proteins, on the epithelial surfaces of the respiratory tract. Although mucin production is associated with the inhibition of virus transmission as well as char...

journal_title：Journal of virology

authors： Nakamura S,Horie M,Daidoji T,Honda T,Yasugi M,Kuno A,Komori T,Okuzaki D,Narimatsu H,Nakaya T,Tomonaga K

更新日期：2015-12-04 00:00:00

abstract：UNLABELLED:The potency and breadth of the recently isolated neutralizing human monoclonal antibodies to HIV-1 have stimulated interest in their use to prevent or to treat HIV-1 infection. Due to the antigenically diverse nature of the HIV-1 envelope (Env), no single antibody is highly active against all viral strains. ...

journal_title：Journal of virology

authors： Asokan M,Rudicell RS,Louder M,McKee K,O'Dell S,Stewart-Jones G,Wang K,Xu L,Chen X,Choe M,Chuang G,Georgiev IS,Joyce MG,Kirys T,Ko S,Pegu A,Shi W,Todd JP,Yang Z,Bailer RT,Rao S,Kwong PD,Nabel GJ,Mascola JR

更新日期：2015-12-01 00:00:00

abstract：UNLABELLED:Despite encoding multiple viral proteins that modulate the retinoblastoma (Rb) protein in a manner classically defined as inactivation, human cytomegalovirus (HCMV) requires the presence of the Rb protein to replicate efficiently. In uninfected cells, Rb controls numerous pathways that the virus also command...

journal_title：Journal of virology

authors： VanDeusen HR,Kalejta RF

更新日期：2015-12-01 00:00:00

abstract：:Hemagglutinin (HA) of H3N2/1968 pandemic influenza viruses differs from the putative avian precursor by seven amino acid substitutions. Substitutions Q226L and G228S are known to be essential for adaptation of avian HA to mammals. We found that introduction of avian-virus-like amino acids at five other HA positions (p...

journal_title：Journal of virology

authors： Van Poucke S,Doedt J,Baumann J,Qiu Y,Matrosovich T,Klenk HD,Van Reeth K,Matrosovich M

更新日期：2015-12-01 00:00:00

abstract：UNLABELLED:Influenza B virus causes annual epidemics and, along with influenza A virus, accounts for substantial disease and economic burden throughout the world. Influenza B virus infects only humans and some marine mammals and is not responsible for pandemics, possibly due to a very low frequency of reassortment and ...

journal_title：Journal of virology

authors： Mäkelä SM,Österlund P,Westenius V,Latvala S,Diamond MS,Gale M Jr,Julkunen I

更新日期：2015-12-01 00:00:00

abstract：UNLABELLED:Transmission of chronic wasting disease (CWD) between cervids is influenced by the primary structure of the host cellular prion protein (PrP(C)). In white-tailed deer, PRNP alleles encode the polymorphisms Q95 G96 (wild type [wt]), Q95 S96 (referred to as the S96 allele), and H95 G96 (referred to as the H95 ...

journal_title：Journal of virology

authors： Duque Velásquez C,Kim C,Herbst A,Daude N,Garza MC,Wille H,Aiken J,McKenzie D

更新日期：2015-12-01 00:00:00

abstract：UNLABELLED:Airway epithelium is the primary target of many respiratory viruses. However, virus induction and antagonism of host responses by human airway epithelium remains poorly understood. To address this, we developed a model of respiratory syncytial virus (RSV) infection based on well-differentiated pediatric prim...

journal_title：Journal of virology

authors： Villenave R,Broadbent L,Douglas I,Lyons JD,Coyle PV,Teng MN,Tripp RA,Heaney LG,Shields MD,Power UF

更新日期：2015-12-01 00:00:00

abstract：UNLABELLED:It was recently reported that 44% of the oropharyngeal samples from the healthy humans in a study cohort had DNA sequences similar to that of the chlorovirus ATCV-1 (Acanthocystis turfacea chlorella virus 1, family Phycodnaviridae) and that these study subjects had decreases in visual processing and visual m...

journal_title：Journal of virology

authors： Petro TM,Agarkova IV,Zhou Y,Yolken RH,Van Etten JL,Dunigan DD

更新日期：2015-12-01 00:00:00

abstract：UNLABELLED:The live attenuated measles virus vaccine is highly immunostimulatory. Identification and characterization of its components that activate the innate immune response might provide new strategies and agents for the rational design and development of chemically defined adjuvants. In this study, we report on th...

journal_title：Journal of virology

authors： Ho TH,Kew C,Lui PY,Chan CP,Satoh T,Akira S,Jin DY,Kok KH

更新日期：2015-11-25 00:00:00

abstract：UNLABELLED:Tetherin (BST2, CD317, or HM1.24) is a host cellular restriction factor that prevents the release of enveloped viruses by mechanically linking virions to the plasma membrane. The precise arrangement of tetherin molecules at the plasma membrane site of HIV-1 assembly, budding, and restriction is not well unde...

journal_title：Journal of virology

authors： Strauss JD,Hammonds JE,Yi H,Ding L,Spearman P,Wright ER

更新日期：2015-11-18 00:00:00

abstract：UNLABELLED:Hepatitis C virus (HCV) is a major cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma in humans. We showed previously that HCV induces autophagy for viral persistence by preventing the innate immune response. Knockdown of autophagy reduces extracellular HCV release, although the precis...

journal_title：Journal of virology

authors： Shrivastava S,Devhare P,Sujijantarat N,Steele R,Kwon YC,Ray R,Ray RB

更新日期：2015-11-18 00:00:00

abstract：UNLABELLED:The porcine sapovirus (SaV) (PoSaV) Cowden strain is one of only a few culturable enteric caliciviruses. Compared to the wild-type (WT) PoSaV Cowden strain, tissue culture-adapted (TC) PoSaV has two conserved amino acid substitutions in the RNA-dependent RNA polymerase (RdRp) and six in the capsid protein (V...

journal_title：Journal of virology

authors： Lu Z,Yokoyama M,Chen N,Oka T,Jung K,Chang KO,Annamalai T,Wang Q,Saif LJ

更新日期：2015-11-18 00:00:00

abstract：UNLABELLED:PML is the organizer of cellular structures termed nuclear domain 10 (ND10) or PML-nuclear bodies (PML-NBs) that act as key mediators of intrinsic immunity against human cytomegalovirus (HCMV) and other viruses. The antiviral function of ND10 is antagonized by viral regulatory proteins such as the immediate ...

journal_title：Journal of virology

authors： Scherer M,Otto V,Stump JD,Klingl S,Müller R,Reuter N,Muller YA,Sticht H,Stamminger T

更新日期：2015-11-11 00:00:00

abstract：UNLABELLED:Protease is essential for retroviral replication, and protease inhibitors (PI) are important for treating HIV infection. HIV-2 exhibits intrinsic resistance to most FDA-approved HIV-1 PI, retaining clinically useful susceptibility only to lopinavir, darunavir, and saquinavir. The mechanisms for this resistan...

journal_title：Journal of virology

authors： Raugi DN,Smith RA,Gottlieb GS,University of Washington-Dakar HIV-2 Study Group.

更新日期：2015-11-11 00:00:00

abstract：UNLABELLED:Pneumonia virus of mice (PVM) is a natural rodent pathogen that replicates in bronchial epithelial cells and reproduces many clinical and pathological features of the more severe forms of disease associated with human respiratory syncytial virus. In order to track virus-target cell interactions during acute ...

journal_title：Journal of virology

authors： Dyer KD,Drummond RA,Rice TA,Percopo CM,Brenner TA,Barisas DA,Karpe KA,Moore ML,Rosenberg HF

更新日期：2015-11-04 00:00:00

abstract：:Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) envelope (Env) proteins are extensively decorated with N-glycans, predominantly of the high-mannose type. However, it is unclear how high-mannose N-glycans on Env impact viral spread. We show that exclusive modification of SIV Env with these N-...

journal_title：Journal of virology

authors： Karsten CB,Buettner FF,Cajic S,Nehlmeier I,Neumann B,Klippert A,Sauermann U,Reichl U,Gerardy-Schahn R,Rapp E,Stahl-Hennig C,Pöhlmann S

更新日期：2015-11-01 00:00:00

abstract：:Production of a vesicular stomatitis virus spike protein G (VSVG)-pseudotyped lentiviral expression vector in HEK293 cells decreased on overexpression of low-density lipoprotein receptor (LDLR) but not that of ICAM1 or TfR1. Reverse transcription-quantitative PCR (RT-qPCR) revealed a reduction in vector RNA as a funct...

journal_title：Journal of virology

authors： Otahal A,Fuchs R,Al-Allaf FA,Blaas D

更新日期：2015-11-01 00:00:00

abstract：UNLABELLED:Testudinid herpesvirus 3 (TeHV-3) is the causative agent of a lethal disease affecting several tortoise species. The threat that this virus poses to endangered animals is focusing efforts on characterizing its properties, in order to enable the development of prophylactic methods. We have sequenced the genom...

journal_title：Journal of virology

authors： Gandar F,Wilkie GS,Gatherer D,Kerr K,Marlier D,Diez M,Marschang RE,Mast J,Dewals BG,Davison AJ,Vanderplasschen AF

更新日期：2015-11-01 00:00:00

abstract：UNLABELLED:The increasing number of zoonotic infections caused by influenza A virus (IAV) subtypes of avian origin (e.g., H5N1 and H7N9) in recent years underscores the need to better understand the factors driving IAV evolution and diversity. To evaluate the current feasibility of global analyses to contribute to this...

journal_title：Journal of virology

authors： Rejmanek D,Hosseini PR,Mazet JA,Daszak P,Goldstein T

更新日期：2015-11-01 00:00:00

abstract：UNLABELLED:Numerous experimental studies have demonstrated that CD8(+) T cells contribute to immunity against influenza by limiting viral replication. It is therefore surprising that rigorous statistical tests have failed to find evidence of positive selection in the epitopes targeted by CD8(+) T cells. Here we use a n...

journal_title：Journal of virology

authors： Machkovech HM,Bedford T,Suchard MA,Bloom JD

更新日期：2015-11-01 00:00:00

abstract：:It is well known that plasmid DNA transfection, prior to virus infection, negatively affects infection efficiency. Here, we show that cytosolic plasmid DNA activates the cGAS/STING signaling pathway, which ultimately leads to the induction of an antiviral state of the cells. Using a transient one-plasmid clustered reg...

journal_title：Journal of virology

authors： Langereis MA,Rabouw HH,Holwerda M,Visser LJ,van Kuppeveld FJ

更新日期：2015-11-01 00:00:00

abstract：UNLABELLED:SSV-type integrases, encoded by fuselloviruses which infect the hyperthermophilic archaea of the Sulfolobales, are archaeal members of the tyrosine recombinase family. These integrases catalyze viral integration into and excision from a specific site on the host genome. In the present study, we have establis...

journal_title：Journal of virology

authors： Zhan Z,Zhou J,Huang L

更新日期：2015-11-01 00:00:00

abstract：UNLABELLED:Despite the nutritional and health benefits of breast milk, breast milk can serve as a vector for mother-to-child HIV transmission. Most HIV-infected infants acquire HIV through breastfeeding. Paradoxically, most infants breastfed by HIV-positive women do not become infected. This is potentially attributed t...

journal_title：Journal of virology

authors： Wahl A,Baker C,Spagnuolo RA,Stamper LW,Fouda GG,Permar SR,Hinde K,Kuhn L,Bode L,Aldrovandi GM,Garcia JV

更新日期：2015-11-01 00:00:00

abstract：UNLABELLED:Next-generation sequence analysis of virus-like particles (VLPs) produced during agroinfiltration of cucumber necrosis virus (CNV) coat protein (CP) and of authentic CNV virions was conducted to assess if host RNAs can be encapsidated by CNV CP. VLPs containing host RNAs were found to be produced during agro...

journal_title：Journal of virology

authors： Ghoshal K,Theilmann J,Reade R,Maghodia A,Rochon D

更新日期：2015-11-01 00:00:00

abstract：:Murine cytomegalovirus (MCMV) proteins m142 and m143 are essential for viral replication. They bind double-stranded RNA and prevent protein kinase R-induced protein synthesis shutoff. Whether the two viral proteins have additional functions such as their homologs in human cytomegalovirus do remained unknown. We show t...

journal_title：Journal of virology

authors： Ostermann E,Warnecke G,Waibler Z,Brune W

更新日期：2015-10-28 00:00:00

abstract：UNLABELLED:Susceptibility or resistance to prion infection in humans and animals depends on single prion protein (PrP) amino acid substitutions in the host, but the agent's modulating role has not been well investigated. Compared to disease incubation times in wild-type homozygous ARQ/ARQ (where each triplet represents...

journal_title：Journal of virology

authors： Langeveld JP,Jacobs JG,Hunter N,van Keulen LJ,Lantier F,van Zijderveld FG,Bossers A

更新日期：2015-10-28 00:00:00

abstract：UNLABELLED:Hepatitis B virus (HBV) infects hundreds of millions of people worldwide and causes acute and chronic hepatitis, cirrhosis, and hepatocellular carcinoma. HBV is an enveloped virus with a relaxed circular (RC) DNA genome. In the nuclei of infected human hepatocytes, conversion of RC DNA from the incoming viri...

journal_title：Journal of virology

authors： Cui X,Clark DN,Liu K,Xu XD,Guo JT,Hu J

更新日期：2015-10-21 00:00:00

abstract：UNLABELLED:Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent for Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and a subset of multicentric Castleman disease (MCD). The KSHV life cycle has two principal gene repertoires, latent and lytic. KSHV viral interleukin-6 (vIL-6), an analog of human ...

journal_title：Journal of virology

authors： Hu D,Wang V,Yang M,Abdullah S,Davis DA,Uldrick TS,Polizzotto MN,Veeranna RP,Pittaluga S,Tosato G,Yarchoan R

更新日期：2015-10-21 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) infection modulates the host cell cycle to create an environment optimal for its viral-DNA replication during the lytic life cycle. We report here that KSHV vIRF4 targets the β-catenin/CBP cofactor and blocks its occupancy on the cyclin D1 promoter, suppressing the G1-S c...

journal_title：Journal of virology

authors： Lee HR,Mitra J,Lee S,Gao SJ,Oh TK,Kim MH,Ha T,Jung JU

更新日期：2015-10-21 00:00:00

abstract：UNLABELLED:PB1-F2 protein, the 11th influenza A virus (IAV) protein, is considered to play an important role in primary influenza virus infection and postinfluenza secondary bacterial pneumonia in mice. The functional role of PB1-F2 has been reported to be a strain-specific and host-specific phenomenon. Its precise con...

journal_title：Journal of virology

authors： Deventhiran J,Kumar SR,Raghunath S,Leroith T,Elankumaran S

更新日期：2015-10-14 00:00:00

abstract：:Transcription of herpesviral late genes is stimulated after the onset of viral DNA replication but otherwise restricted. Late gene expression in gammaherpesviruses requires the coordination of six early viral proteins, termed viral transactivation factors (vTFs). Here, we mapped the organization of this protein comple...

journal_title：Journal of virology

authors： Davis ZH,Hesser CR,Park J,Glaunsinger BA

更新日期：2015-10-14 00:00:00

abstract：:Influenza A virus infection can arrest autophagy, as evidenced by autophagosome accumulation in infected cells. Here, we report that this autophagosome accumulation can be inhibited by amantadine, an antiviral proton channel inhibitor, in amantadine-sensitive virus infected cells or cells expressing influenza A virus ...

journal_title：Journal of virology

authors： Ren Y,Li C,Feng L,Pan W,Li L,Wang Q,Li J,Li N,Han L,Zheng X,Niu X,Sun C,Chen L

更新日期：2015-10-14 00:00:00